5 Amino 1MQ Lyophilized Powder 50 mg
High-Purity Lyophilized Powder
$83.00
Nomenclature & Synonyms
The compound known as 5-Amino-1MQ is chemically referred to as 5-Amino-1-methylquinolinium. There are no widely reported specific research or development codes associated with this compound in public literature. It is structurally derived from quinolinium compounds.
Structural Characteristics
5-Amino-1MQ is not a peptide and does not have an amino acid sequence. Its structure includes a quinolinium core with a methyl group at the first position and an amino group at the fifth position, which is crucial for its activity. It does not possess peptide bond modifications, such as N-terminal acetylation or C-terminal amidation, but the presence of the amino group is central to its functional properties.
Molecular Pharmacology
5-Amino-1MQ targets the enzyme nicotinamide N-methyltransferase (NNMT), and it acts as an inhibitor. Its inhibition mechanism has been primarily associated with downregulating the methylation pathway, affecting NAD+ and energy metabolism. Currently, detailed EC50/IC50 values are not broadly documented in literature. The compound has been shown to alter metabolic pathways related to nicotinamide-adenine-dinucleotide (NAD+) levels and sirtuin signaling.
Research Applications
First synthesized and described in the early 2000s, 5-Amino-1MQ has primarily been investigated in cellular models related to metabolic studies.
Studies have demonstrated its impact on modulating metabolic rate and energy expenditure in vitro.
Investigations focus on its role within systems where nicotinamide metabolism is critical.
Technical Properties
5-Amino-1MQ is soluble in dimethyl sulfoxide (DMSO) and can be solubilized at concentrations up to 10 mg/mL for experimental applications. For stability, the compound should be stored in a dry, light-protected environment and reconstituted solutions should be used promptly to ensure efficacy. Lyophilized powder remains stable under recommended storage conditions.
Compliance
For laboratory research use only. Not for human or veterinary use. Not intended for diagnostic, therapeutic, or preventive applications.