DSIP Lyophilized Powder 15mg

Nomenclature & Synonyms

Delta sleep-inducing peptide (DSIP), identified by its sequence Glu-Ala-Glu-Asp-Gly-Gly-Ser-Ala, is a neuropeptide of nonapeptide structure. Initially, it was described without any associated research codes or development codes and has been predominantly referred to by its abbreviation in scientific literature.

Structural Characteristics

The DSIP is composed of 9 amino acids: H-Glu-Ala-Glu-Asp-Gly-Gly-Ser-Ala-Glu-OH. It lacks complex structural modifications such as disulfide bridges or terminal acetylations. This peptide does not represent a fragment from a larger parent protein but is synthesized as a complete neuropeptide.

Molecular Pharmacology

DSIP does not have well-defined receptor targets due to its elusive mechanism of action in vivo. Its purported roles involve modulating activities such as sleep by interacting indirectly with various neurotransmitter systems, but specific pathways like cAMP/PKA or MAPK/ERK have not been definitively linked. Current data do not offer EC50/IC50 values, limiting specific pharmacokinetic profiling.

Research Applications

• First synthesized and described by Swiss researchers during the 1970s.

• Investigated primarily in central nervous system models, focusing on sleep regulation and stress modulation.

• Studies have demonstrated potential regulatory effects on endogenous opioid systems and modulation of hormonal secretion in vitro.

Technical Properties

DSIP is highly soluble in sterile water, typically at concentrations of 1 mg/mL. For laboratory research, it is recommended to reconstitute lyophilized powder immediately before use. Stability is maintained under lyophilized conditions; however, reconstituted solutions should be stored at -20°C to prevent degradation.

Compliance

For laboratory research use only. Not for human or veterinary use. Not intended for diagnostic, therapeutic, or preventive applications.