KPV Lyophilized Powder 10mg

Nomenclature & Synonyms

The peptide Lysine-Proline-Valine, often abbreviated as KPV, is identified by its amino acid sequence. It does not have widely published research or development codes, but is referred to simply as KPV in scholarly articles. It is a tripeptide analogue derived from the protein proopiomelanocortin (POMC), although it is not a direct fragment of POMC.

Structural Characteristics

The amino acid sequence of KPV is H-Lys-Pro-Val-OH, consisting of three amino acids. No specific post-translational modifications, such as acetylation or amidation, are reported for this peptide. Its short linear sequence contributes to its potential for stability and interaction with receptor sites.

Molecular Pharmacology

KPV is predominantly recognized for its interaction with the melanocortin receptor subtype, particularly the MC1R (melanocortin 1 receptor), where it acts as an agonist. Studies suggest it influences the anti-inflammatory pathway by inhibiting the NF-κB signaling cascade, though exact EC50/IC50 values are not extensively documented. Its selectivity profile is notable, with significant action on the MC1R compared to other melanocortin receptors.

Research Applications

• First described in academic literature in the early 2000s as part of studies on anti-inflammatory peptides.

• Investigated in vitro for its capacity to modulate inflammatory pathways in cellular models, particularly those involving immune responses.

• Studies have demonstrated its potential to reduce pro-inflammatory cytokines.

Technical Properties

KPV is moderately soluble in sterile distilled water at concentrations of up to 1mg/mL. For research purposes, lyophilized KPV is stable when stored at -20°C and should be reconstituted with appropriate sterile solutions prior to use. Once reconstituted, it remains stable for several days at 4°C.

Compliance

For laboratory research use only. Not for human or veterinary use. Not intended for diagnostic, therapeutic, or preventive applications.